Publications
Palidis DJ, McGregor HR, Vo A, MacDonald PA, Gribble PL. (2021) Null effects of levodopa on reward- and error-based motor adaptation, savings, and anterograde interference. Journal of Neurophysiology. 2021:47-67.
Prenger MTM, Madray R, Van Hedger K, Anello M, MacDonald PA. (2020) Social Symptoms of Parkinson’s Disease. Parkinson’s Disease. 2020;2020:8846544.
Hiebert NM, Lawrence MR, Ganjavi H, Watling M, Owen AM, Seergobin KN, MacDonald PA. (2020) Striatum-Mediated Deficits in Stimulus-Response Learning and Decision-Making in OCD. Frontiers in Psychiatry. 2020;11:13.
MacDonald AA, Rajendram P, Kamra M, Murray BJ, MacDonald PA, Boulos MI. (2020) Predictors of in laboratory polysomnography attendance in a cohort of patients with stroke or TIA. Sleep Medicine. 66:159-164.
Al Jaja A, Grahn JA, Herrmann B, MacDonald PA. (2020) The effect of aging, Parkinson’s disease, and exogenous dopamine on the neural response associated with auditory regularity processing. Neurobiology of Aging. 2020;89:71-82.
Hiebert NM, Lawrence MR, Ganjavi H, Watling M, Owen AM, Seergobin KN, MacDonald PA. (2020) Striatum-Mediated Deficits in Stimulus-Response Learning and Decision-Making in OCD. Frontiers in Psychiatry. 2020;11.
Witt I, Ganjavi H, MacDonald PA. (2019) Relationship between Freezing of Gait and Anxiety in Parkinson’s Disease Patients: A Systemic Literature Review. Parkinson’s Disease. 2019;2019:6836082.
Yabe Y, Goodale MA, and MacDonald PA. (2019) Investigating the perceived timing of sensory events triggering actions in patients with Parkinson’s disease and the effects of dopaminergic therapy. Cortex. 2019;115:309-323.
Silveira CRA, MacKinley J, Coleman K, Li Z, Finger E, Bartha R, Morrow SA, Wells J, Borrie M, Tirona RG, Rupar CA, Zou G, Hegele RA, Mahuran D, MacDonald PA, Jenkins ME, Jog M, Pasternak SH. (2019) Ambroxol as a novel disease-modifying treatment for Parkinson’s disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial. BMC Neurology. Volume 19 (1):20. doi: 10.1186/s12883-019-1252-3.
Hiebert NM, Owen AM, Ganjavi H, Mendonça D, Jenkins ME, Seergobin KN, and MacDonald PA.(2019) Dorsal striatum does not mediate feedback-based, stimulus-response learning. NeuroImage. 2019 Jan 15;185:455-470.
Khan AR, Hiebert NM, Vo A, Wang BT, Owen AO, Seergobin KN, MacDonald, PA. (2019). Biomarkers of Parkinson’s disease: Striatal sub-regional structural morphometry and diffusion MRI. NeuroImage: Clinical. 2019;21:101597.
Prenger, M. & MacDonald, PA.. (2018). Problems with Facial Mimicry Might Contribute to Emotion Recognition Impairment in Parkinson’s Disease. Parkinson’s Disease. 2018 Nov 11;2018:5741941.
Robertson BD, Al Jaja AS, MacDonald AA, Hiebert NM, Tamjeedi R, Seergobin KN, Schwarz UI, Kim RB, MacDonald PA. (2018). SLC6A3 Polymorphism Predisposes to Dopamine Overdose in Parkinson’s Disease. Front Neurol. 2018 Aug 21;9:693. doi: 10.3389/fneur.2018.00693. eCollection 2018.
Vo A, Seergobin KN, MacDonald, PA. (2018). Independent effects of age and levodopa on reversal learning in healthy volunteers. Neurobiology of Aging. Volume 69, September 2018, Pages 129-139. https://doi.org/10.1016/j.neurobiolaging.2018.05.014
Vo A, Ganjavi H, MacDonald PA (2018). Levodopa has mood‐enhancing effects in healthy elderly adults. International journal of geriatric psychiatry. 33 (4), 674-675.
Yang XQ, Lauzon B, Seergobin KN, and MacDonald PA. (2018). Dopaminergic Therapy Increases Go Timeouts in the Go/No-go Task in Patients with Parkinson’s Disease. Frontiers in Human Neuroscience. Jan 4;11:642. doi: 10.3389/fnhum.2017.00642. eCollection 2017.
Hiebert NM, Owen AM, Seergobin KN, and MacDonald PA. (2017). Dorsal Striatum Mediates Deliberate Decision Making, Not Late-stage, Stimulus-response Learning. Human Brain Mapping 38 (12), 6133-6156.
Merritt K, Seergobin KN, Mendonca D, Jenkins M, Goodale M, MacDonald PA. (2017). Automatic Online Motor Control is Intact in Parkinson’s Disease With and Without Perceptual Awareness. eNeuro 4 (5).
Vo A, Seergobin KN, MacDonald PA. (2017). Effects of levodopa on stimulus-response learning versus response selection in healthy young adults. Behavioural Brain Research. 317:553-561.
Dayal AM, Jenkins ME, Jog MS, Kimpinski K, MacDonald P, Gofton TE. (2017). Palliative Care Discussions in Multiple System Atrophy: A Retrospective Review. Canadian Journal of Neurological Sciences, 1-7.
Vo A, Seergobin KN, MacDonald PA. (2016). Effects of levodopa on reversal learning in healthy volunteers: implications for Parkinson’s disease. Psychopharmacology.
Glizer D, MacDonald PA. (2016). Cognitive Training in Parkinson’s Disease: A Review of Studies from 2000 to 2014. Parkinson’s Disease. 2016: 9291713.
Vo A, Seergobin KN, Morrow SA, MacDonald PA. (2016). Levodopa impairs probabilistic reversal learning in healthy young adults. Psychopharmacology. 233: 2753–2763.
Yang XQ, Glizer D, Vo A, Seergobin K, MacDonald PA. (2016). Pramipexole Increases Go Timeouts but Not No-go Errors in Healthy Volunteers. Frontiers in Neuroscience. Volume 10. Article 523.
Welk B, McArthur E, Morrow SA, MacDonald P, Hayward J, Leung A, Lum A. (2016). Association Between Gadolinium Contrast Exposure and the Risk of Parkinsonism. JAMA. 316: 96.
Hampshire A, Hellyer PJ, Parkin B, Hiebert N, MacDonald P, Owen AM, Leech R, Rowe J. (2016). Network mechanisms of intentional learning. Neuroimage. 127:123-34. doi: 10.1016/j.neuroimage.2015.11.060. Epub 2015 Dec 4. PMID: 26658925
Ganjavi H, MacDonald PA. (2015). ON-OFF Effects of Dopaminergic Therapy on Psychiatric Symptoms in Parkinson’s Disease. Journal of Neuropsychiatry and Clinical Neuroscience. 27(2): 134-139.
MacDonald AA, Naci L, MacDonald PA, Owen AM. (2015). Anesthesia and neuroimaging: investigating the neural correlates of unconsciousness. Trends in Cognitive Science. 19(2): 100-107.
Robertson BD, Hiebert NM, Seergobin KN, Owen AM, MacDonald PA. (2015). Dorsal striatum mediates cognitive control, not cognitive effort per se, in decision-making: An event-related fMRI study. Neuroimage. 114: 170-184.
Burgaleta M, Macdonald PA, Martínez K, Román FJ, Alvarez-Linera J, González AR, Karama S, Colom R. (2014). Subcortical regional morphology correlates with fluid and spatial intelligence. Human Brain Mapping. EPUB Aug 2, 2013.
Ganjavi H, Siu V, Speevak M, MacDonald PA. (2014). A fourth case of Feingold syndrome type 2: psychiatric presentation and management. BMJ Case Reports. 0: 2014.
Hiebert NM, Seergobin KN, Vo A, Ganjavi H, MacDonald PA. (2014). Dopaminergic therapy affects learning and impulsivity in Parkinson’s disease. Annals of Clinical and Translational Neurology. 1(10):833-843.
Hiebert NM, Vo A, Seergobin KN, Hampshire A, Owen AM, MacDonald PA. (2014). Striatum in stimulus-response learning via feedback and decision making. Neuroimage. [Link]
Linton B, Fu R, MacDonald PA, Ganjavi H. (2014). Burning pain secondary to clozapine use: a case report. BMC Psychiatry.
MacDonald AA, Seergobin KN, Tamjeedi R, Owen AM, Provost JS, Monchi O, Ganjavi H, MacDonald PA. (2014). Examining dorsal striatum in cognitive effort using Parkinson’s disease and fMRI. Annals of Clinical and Translational Neurology. [Link]
MacDonald PA, Ganjavi H, Collins DL, Evans AC, Karama S. (2014). Investigating the relation between striatal volume and IQ. Brain Imaging and Behavior. [Link] EPUB 2013.
Vo A, Hiebert NM, Seergobin KN, Solcz S, Partridge A, MacDonald PA. (2014). Dopaminergic medication impairs learning but not decision making in Parkinson’s disease. Frontiers in Human Neuroscience.
MacDonald AA, Monchi O, Seergobin KN, Ganjavi H, Tamjeedi R, MacDonald PA. Parkinson’s disease duration determines effect of dopaminergic therapy on ventral striatum function. Movement Disorders. 2013 Feb;28(2):153-60. doi: 10.1002/mds.25152. Epub 2012 Nov 19.
MacDonald AA, Seergobin KN, Owen AM, Tamjeedi R, Monchi O, Ganjavi, H, & MacDonald, PA. (2013). Differential Effects of Parkinson’s Disease and Dopamine Replacement on Memory Encoding and Retrieval. PLoS ONE 8(9): e74044. doi:10.1371/journal.pone.0074044
Ganjavi, H., Evans, A. C., Lewis, J, MacDonald, P. A., Karama, S., & the NIH MRI Study of Normal Brain Development Group. (2011). Negative associations between corpus callosum midsagittal area and IQ in a representative sample of healthy children and adolescents. PLoSONE,6(5):e19698.
MacDonald, P. A., MacDonald, A. A., Seergobin, K. N., Tamjeedi, R., Ganjavi, H., Provost, Jean-Sebastien, & Monchi, O. (2011). The effect of dopamine therapy on ventral and dorsal striatum-mediated cognition in Parkinson’s disease: Support from fMRI. Brain 134, 1447-1463.
MacDonald, P. A. & Monchi, O. (2011). Differential effects of dopaminergic therapies on cognition in Parkinson’s Disease. Parkinson’s Disease, 572743.
Joch, M., Ase, A. R., Chen, C. X., MacDonald, P. A., Kontogiannea, M., Corera, A. T., Brice, A., Seguela, P., & Fon, E. A. (2007). Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels. Molecular Biology of the Cell, 18, 3105-3118.
MacDonald, P. A., & Paus, T. (2003). The role of parietal cortex in the awareness of self-generated movements: A transcranial magnetic stimulation study. Cerebral Cortex, 16, 962-967.
MacDonald, P. A., & Joordens, S. (2000). Investigating a memory-based explanation of negative priming: Support for a selection-feature mismatch account. Journal of Experimental Psychology: Human Perception and Performance, 26, 1478-1496.
MacLeod, C. M., & MacDonald, P. A. (2000). Interdimensional interference in the Stroop effect: uncovering the cognitive and neural anatomy of attention. Trends in Cognitive Sciences, 4, 383-391.
MacDonald, P. A., Antony, M. M., MacLeod, C. M., & Swinson, R. P. (1999). Negative priming for Obsessive-Compulsive checkers, noncheckers and nonclinical controls. Journal of Abnormal Psychology, 108, 679-686.
MacDonald, P. A., Joordens, S., & Seergobin, K. N. (1999). Negative priming effects that are bigger than a bread box: Attention to distractors does not eliminate negative priming. Memory & Cognition, 27, 197-207.
MacDonald, P. A., & MacLeod, C. M. (1998). The influence of attention at encoding on direct and indirect tests of memory. Acta Psychologica, 98, 291-310.
MacDonald, P. A., Antony, M. M., MacLeod, C. M., & Richter, M. A. (1997). Memory and confidence in memory judgments among individuals with Obsessive Compulsive disorder and non-clinical controls. Behaviour Research and Therapy, 35, 497-505.
Selected Oral Presentations (since 2012)
Presenter, International Conference on Alzheimer’s and Parkinson’s Disease, Lisbon, Portugal, Biomarkers of Parkinson’s Disease: Striatal sub-regional structural morphometry and diffusion MRI, 2019 Mar
Invited Lecturer, Discover Robarts Community Presentation Series, It’s not just Alzheimer’s Disease: Frontotemporal Dementia and Parkinson’s Disease, 2019 Feb
Invited Lecturer, Neuroimaging in Parkinson’s Disease and Related Disorders Symposium, Calgary, Alberta, Canada, Dopaminergic therapy enhances dorsal and attenuates ventral striatum functions and corresponding fMRI BOLD signal in Parkinson’s disease, 2017 June 9
Invited Lecturer, MEETING OF BRAINS & MINDS: Joint Symposium University of Geneva (UNIGE) & University of Western Ontario (UWO), Geneva, Genève (fr), Switzerland, Investigating cognition in Parkinson’s disease, 2016 Jul 1
Invited Lecturer, Department of Psychiatry Monthly Rounds, University of Western Ontario, London, Ontario, Canada, Cognitive and psychiatric manifestations of Parkinson’s Disease, 2016 May 12
Invited Lecturer, Department of Clinical Neurological Sciences Grand Rounds, University of Western Ontario, London, Ontario, Canada, Investigating cognition in Parkinson’s disease and cognitive functions mediated by the striatum, 2015 Sep 29
Invited Lecturer, 4th Annual McMaster Neuroscience Symposium, Hamilton, Ontario, Canada, Cognition in Parkinson’s Disease and the Effect of Dopaminergic Therapy, 2015 May 8
Invited Lecturer, Division of Neuropsychiatry, University of Western Ontario, London, Ontario, Canada, Dorsal striatum’s role in learning, 2015 Jan 23
Presenter, Translational Research Club, Schulich School and Medicine & Dentistry, Undergraduate Medicine Program, London, Ontario, Canada, Distinguishing cognitive functions mediated by ventral and dorsal striatum, 2014 May 6
Presenter, Department of Physiology and Pharmacology, London, Ontario, Canada, Investigating Cognitive Functions Mediated by Ventral and Dorsal Striatum. Department of Physiology and Pharmacology Seminar Presentation, University of Western Ontario, 2013 Apr 26
Keynote Speaker, Parkinson’s Society of Northern and Central Ontario, Sudbury, Ontario, Canada, Parkinson’s Disease: Recognizing the Symptoms and Understanding the Treatments. Keynote Speaker at Parkinson’s Society of Northern and Central Ontario conference on Making the Most of Life with Parkinson’s Disease, Parkinson’s Society of Northern and Central Ontario Plenary Presentation, 2012 Sep
Selected Abstract/Poster Presentations (since 2012)
MacDonald PA, Hiebert NM, Naci L, Owen AM, Functional Biomarkers of Parkinson’s Disease: Changes in Brain-Wide Network Connectivity in Default Mode and Frontal-Parietal Control Networks, 2019 May, Annual meeting of the American Academy of Neurology, Philadelphia, Pennsylvania, United States
MacDonald PA, Hiebert NM, Owen AM, Ganjavi H, Jenkins M, Mendonca D, Seergobin KN, Dorsal Striatum Does Not Mediate Feedback-Based, Stimulus-Response Learning, 2019 May, Annual meeting of the American Academy of Neurology, Philadelphia, Pennsylvania, United States
MacDonald PA, Biomarkers of Parkinson’s disease: Striatal sub-regional structural morphometry and diffusion MRI, 2017 Jun, Neuroimaging in Parkinson’s Disease and Related Disorders Symposium, Calgary, Alberta, Canada
Yabe Y, MacDonald PA, Goodale MA, Perceived timing of sensory events triggering actions in Parkinson’s disease, 2016 Jul, Annual Meeting of the Japan Neuroscience Society, Yokohama, Kanagawa, Japan
MacDonald PA, Vo, A, Seergobin KN, Levodopa impairs learning in healthy young adults: Implications for Levocarb in Parkinson’s disease, 2016 Jun, Annual Meeting of the Organization of Human Brain Mapping, Geneva, Genève (fr), Switzerland
MacDonald PA, Vo A, Seergobin KN, Levodopa impairs learning in healthy young adults: Implications for Levocarb in Parkinson’s disease, 2016 Jun, International Congress on Parkinson’s disease and Movement Disorders, Berlin, Berlin, Germany
MacDonald PA, Hiebert NM, Owen AM, Seergobin KN, Does Dorsal Striatum Mediate Stimulus-Response Learning or Decision Making? Paper presented at annual meeting of the American Academy of Neurology, 2015 Apr, Annual meeting of the American Academy of Neurology, Washington, District of Columbia, United States
Hiebert NM, Owen AM, Seergobin KN, MacDonald PA, Investigating dorsal striatum’s role in response selection and stimulus-response learning. International Conference on Alzheimer’s and Parkinson’s Diseases, 2015 Mar 19, International Conference on Alzheimer’s and Parkinson’s Disease, Nice, Alpes-Maritimes, France
Robertson BD, Hiebert NM, Seergobin KN, Owen AM, MacDonald PA, Dorsal striatum mediates cognitive control, not cognitive effort per se: An event-related fMRI study. 2015 Mar 19, International Conference on Alzheimer’s and Parkinson’s Disease, Nice, Alpes-Maritimes, France